I've created a mailing list for discussing potential wrappers for wxPython.
http://lists.sourceforge.net/lists/listinfo/montywxpython-devel
The list is also available via gmane:
gmane.comp.python.montywxpython
There is no particular goal initially other than getting discussion of this type of topic off of wxPython-users <wink> I expect that many different viewpoints will be expressed, so if you have opinions on fixing, improving or simplifying the wxPython API come on over and get your opinions off your chest.
ka