Hi. I am a PyPy dev. Today I tried building wxPython Phoenix using PyPy, and would like to share my experience .
It took me a while to find the github repo, the wiki and web site do not seem to mention it AFAICT. In fact, the buildbot instructions here https://wiki.wxpython.org/ProjectPhoenix/BuildbotSlave tricked me into thinking that SVN was still the preferred method of source control for the project. But once I found the github repo https://github.com/wxWidgets/Phoenix everything became easier.
Since I am using a dev version of PyPy (not packaged by the Debian maintainer, rather the nightly HEAD), I needed to roll my own pypy-config based on the python27-config script.
Of course, the build immediately crashed since our C-API compatibility is not yet good enough. We seem to have some badly declared function signatures that do not match CPython, I will be fixing these over the next few weeks, and may need to submit patches or fixes for too heavy-duty use of c pointers that I cannot fix on the PyPy side of things.
I would love to get the wxPython toolkit working under PyPY, so I hope there are not too many patches needed.
FWIW, we did try to use CFFI instead of the C-API a few years back during a Google Summer of Code, the results are languishing on https://bitbucket.org/waedt/wxpython_cffi.
So thanks for wxPython, and stay tuned, hopefully I can make some progress here